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The paper studies methodological aspects of innovative development diagnostics of a region. These aspects are illustrated by results of factor, regression and cluster analyses of the innovative development indicators that are used to create innovation profiles of Russia and Siberian Federal District in 2007 and 2010. Differences in the set of factors and indicators that statistically explain the innovative development in the country and the region in different years are demonstrated. Using cluster analysis three groups of Siberian regions with similar innovation profiles are established. Regressions of gross regional product on the innovative activity indicators of the Siberian regions and Russia are built.
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