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Introduction and Background In the ADEPT 1 project [ADEPT] we are looking at different facets of advanced process-oriented information systems in conjunction with each other: Component-based application development, exception handling and flexibility issues, dynamic workflow changes, temporal aspects, workflow evolution, inter-workflow dependencies, man-machine interfaces, scalability, and WfMS architectures and implementation. The roots of the ADEPT project go back into the year 1992, when the interdisciplinary research project "Open Clinical Information and Database System for the Integration of Autonomous Subsystems" (OKIS, 1992-94) started. The intensive discussions we had with the medical personnel and the investigations performed within the OKIS project have made clear to us that "passive", data-centric information systems alone are by far not sufficient to solve the pressing problems found in most clinical application areas. Being conf
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