Localization and characterization of vasopressin-binding sites in the amygdala of the rat brain

Daniel M. Dorsa · Frances M. Petracca · DG Baskin · L.E. Cornett

66 citations0/0 files storedJournal of Neuroscience

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Neuroendocrine regulation and behavior Neuroscience and Neuropharmacology Research Neuropeptides and Animal Physiology

Abstract

Putative receptors for arginine-vasopressin (AVP) in rat brain were localized and characterized using autoradiographic and radioligand-binding techniques. When brain slices were incubated with tritium-labeled vasopressin, an intense concentration of binding sites was identified which included the medial aspects of the amygdala. Binding of labeled AVP to membrane preparations from this brain region was saturable, specific, reversible, and of high affinity. An antagonist of the peripheral pressor activity of vasopressin was found to be a potent competitor for binding to this site.

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References

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1988Testosterone alters the behavioral response of the medial preoptic-anterior hypothalamus to microinjection of arginine vasopressin in the hamster 1988Quantitative autoradiographic mapping of neurohypophysial hormone binding sites in the rat forebrain and pituitary gland—I. Characterization of different types of binding sites and their distribution in the long-evans strain 1988Subcellular Localization and Characterization of Vasopressin Binding Sites in the Ventral Septal Area, Lateral Septum, and Hippocampus of the Rat Brain

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