Cross‐modal reorganization of cortical afferents to dorsal auditory cortex following early‐ and late‐onset deafness

Melanie A. Kok · Nicole Chabot · Stephen G. Lomber

75 citations0/0 files storedThe Journal of Comparative Neurology

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Multisensory perception and integration Neuroscience and Music Perception Tactile and Sensory Interactions

Abstract

Cat auditory cortex is known to undergo cross-modal reorganization following deafness, such that behavioral advantages in visual motion detection are abolished when a specific region of deaf auditory cortex, the dorsal zone (DZ), is deactivated. The purpose of the present investigation was to examine the connectional adaptations that might subserve this plasticity. We deposited biotinylated dextran amine (BDA; 3,000 MW), a retrograde tracer, unilaterally into the posterior portion of the suprasylvian fringe, corresponding to area DZ of hearing, early-deafened (onset <1 month), and late-deafened (onset >3 months) cats to reveal cortical afferent projections. Overall, the pattern of cortical projections to DZ was similar in both hearing and deafened animals. However, there was a progressive increase in projection strength among hearing and late- and early-deafened cats from an extrastriate visual cortical region known to be involved in the processing of visual motion, the posterolateral lateral suprasylvian area (PLLS). Additionally, although no such change was documented for the posteromedial lateral suprasylvian area (PMLS), labeled neurons were present within a subregion of PMLS devoted to foveal vision in both late- and early-deafened animals but not in hearing controls. PMLS is also an extrastriate visual motion processing area and is widely considered to be the homolog of primate middle temporal area. No changes in auditory cortical connectivity were observed among groups. These observations suggest that amplified cortical projections from extrastriate visual areas involved in visual motion processing to DZ may contribute to the cross-modal reorganization that functionally manifests as superior visual motion detection ability in the deaf animal.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 75 citations exist upstream.

References

2002Anatomical Evidence of Multimodal Integration in Primate Striate Cortex 2003Multisensory convergence in calcarine visual areas in macaque monkey 2010Cross-modal plasticity in specific auditory cortices underlies visual compensations in the deaf 2000Visual Attention to the Periphery Is Enhanced in Congenitally Deaf Individuals 2006Multisensory processing via early cortical stages: Connections of the primary auditory cortical field with other sensory systems 2012Altered Cross-Modal Processing in the Primary Auditory Cortex of Congenitally Deaf Adults: A Visual-Somatosensory fMRI Study with a Double-Flash Illusion 2009Anatomical connections suitable for the direct processing of neuronal information of different modalities via the rodent primary auditory cortex 2011Crossmodal reorganization in the early deaf switches sensory, but not behavioral roles of auditory cortex

Cited by

2016Changed crossmodal functional connectivity in older adults with hearing loss 2015Amplified somatosensory and visual cortical projections to a core auditory area, the anterior auditory field, following early‐ and late‐onset deafness 2015Differential modification of cortical and thalamic projections to cat primary auditory cortex following early‐ and late‐onset deafness

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.