Frequency and risk factors for donor reactions in an anonymous blood donor survey

Mindy Goldman · Lori Osmond · Qilong Yi · Keltie Cameron‐Choi · Sheila F. O’Brien

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Blood donation and transfusion practices Blood transfusion and management Ethics in Clinical Research

Abstract

BACKGROUND: Adverse donor reactions can result in injury and decrease the likelihood of donor return. Reaction reports captured in the blood center's database provide an incomplete picture of reaction rates and risk factors. STUDY DESIGN AND METHODS: We performed an anonymous survey, mailed to 40,000 donors in 2008, including questions about symptoms, height, weight, sex, and donation status. Reaction rates were compared to those recorded in our database. Possible risk factors were assessed for various reactions. RESULTS: The response rate was 45.5%. A total of 32% of first-time and 14% of repeat donors reported having any adverse symptom, most frequently bruising (84.9 per 1000 donors) or feeling faint or weak (66.2 per 1000). Faint reactions were two to eight times higher than reported in our database, although direct comparison was difficult. Younger age, female sex, and first-time donation status were risk factors for systemic and arm symptoms. In females, low estimated blood volume (EBV) was a risk factor for systemic symptoms. Only 51% of donors who consulted an outside physician also called Canadian Blood Services. A total of 10% of first-time donors with reactions found adverse effects information inadequate. CONCLUSION: This study allowed us to collect more information about adverse reactions, including minor symptoms and delayed reactions. Based on our findings of the risk factors and frequency of adverse reactions, we are implementing more stringent EBV criteria for younger donors and providing more detailed information to donors about possible adverse effects and their management.

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References

1977Standards for blood banks and transfusion services.2006The effect of whole‐blood donor adverse events on blood donor return rates 2003Adverse effects in blood donors after whole‐blood donation: a study of 1000 blood donors interviewed 3 weeks after whole‐blood donation 2008Adverse Reactions to Allogeneic Whole Blood Donation by 16- and 17-Year-Olds 2008Faint and prefaint reactions in whole‐blood donors: an analysis of predonation measurements and their predictive value 2008The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006 2003Mild reactions to blood donation predict a decreased likelihood of donor return 2009BLOOD DONORS AND BLOOD COLLECTION: Delayed adverse reactions to blood donation

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2016The Blood Donor Anxiety Scale: a six‐item state anxiety measure based on the Spielberger State‐Trait Anxiety Inventory 2015First-time whole blood donation: A critical step for donor safety and retention on first three donations 2021Plasmavigilance—Adverse events among US Source plasma donors 2021Blood Donation-Related Adverse Reactions: Results of an Online Survey among Donors in Germany (2018)

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