Building a Laboratory Information System Around a C++-Based Object-Oriented DBMS

Abstract

MapBase is a laboratory information system that has been supporting a high-throughput genome-mapping operation for the last three years. We chose to build MapBase around a C++-based OODBMS because, like CAD, CASE, and GIS applications, MapBase must be able to represent complex data and operations while providing fast response. However, MapBase also turned out to share many characteristics of classical information systems: it provides a central repository of carefully administered, mission-critical data used by clients written in many languages and running on a variety of hardware. In addition, our laboratory emphasizes continuous process re-engineering, with the result that MapBase's schema must evolve rapidly in order to reflect the current experimental workflow. We discuss how the technical characteristics This work was supported by funds from the National Institutes of Health, National Center for Human Genome Research, grant number P50 HG00098. PostScript version of this paper av...

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