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The significance of circadian rhythms in aerospace operations is discussed under the following aspects: Characteristics and interrelationship of environmental and biological circadian systems; Circadian rhythms of mental and physical performance, as well as of susceptibility and resistance; Modification of circadian cycling through external and internal factors; Disturbance of circadian rhythmicity and sleep-wake cycling in air and space operations and shiftwork; Consequences for performance efficiency and health; Formulas, models and rest duty regulations; and Recommendations for the passenger, crew and management. Finally, the 'Biorhythm Theory' is critically reviewed.
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