Machina Carnis: The Biochemistry of Muscular Contraction in its Historical Development

Abstract

Preface 1. Bringing muscles into focus: the first two millennia 2. Muscle metabolism after the Chemical Revolution 3. the relationship between mechanical events, heat production and metabolism 4. The influence of brewing science on the study of muscle glycolysis 5. The discovery of phosphagen and adenosinetriphosphate 6. Adenosinetriphosphate as fuel and as phosphate-carrier 7. Early studies of msucle structure and theories of contraction 8. Interaction of actomyosin and ATP 9. Some theories of contraction mechanism 10. On myosin, actin and tropomyoson 11. The sliding mechanism 12. How does the sliding mechanism work? 13. Excitation, excitation-contraction coupling and relaxation 14. Happenings in intact muscle 15. Rigor and the chemical changes responsible for its onset 16. Respiration 17. Oxidative phosphorylation 18. The regulation of carbohydrate metabolism for energy supply to the muscle machine 19. A comparative study of the striated muscle of vertebrates 20. Enzymic and other effects of denervation, cross-innervation and repeated stimulation 21. some aspects of muscle disease 22. Contraction in muscles of invertebrates 23. Vertebrate smooth muscle 24. Energy provision and contactile proteins in non-muscular functions References.

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