The Generation of Diversity: Clonal Selection Theory and the Rise of Molecular Immunology

Scott H. Podolsky · Alfred I. Tauber

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Philosophy and History of Science T-cell and B-cell Immunology Historical Medical Research and Treatments

Abstract

A conceptual orientation the Burnet legacy CST and molecular immunology - a dogmatic alliance interlude - the conventional history germline, somatic mutation and recombinatorial models - 1960-1974 immunobiological theories of antibody diversity from protein to DNA the recombinant revolution interlude - a historigraphic reappraisal heavy chain diversity and the molecular finale an accounting the fate of the immune self.

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2008The Immune System and Its Ecology 1998Conceptual Shifts in Immunology: Comments on the ‘Two-Way Paradigm’2008Cancer, Viruses, and Mass Migration: Paul Berg’s Venture into Eukaryotic Biology and the Advent of Recombinant DNA Research and Technology, 1967–1980 1999The Elusive Immune Self: A Case of Category Errors 2002Theory testing in experimental biology: the chemiosmotic mechanism of ATP synthesis 2000The Professionalization of Science Studies: Cutting Some Slack 2010Science and the quest for meaning 2000Selfhood, Immunity, and the Biological Imagination: The Thought of Frank Macfarlane Burnet

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