Sugar Bingeing in Rats

Nicole M. Avena · Pedro V. Rada · Bartley G. Hoebel

66 citations0/0 files storedCurrent Protocols in Neuroscience

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Eating Disorders and Behaviors Neurotransmitter Receptor Influence on Behavior Regulation of Appetite and Obesity

Abstract

Bingeing behavior is characteristic of many eating disorders. This unit describes an animal model of sugar bingeing. This model has been used successfully to elicit behavioral and neurochemical signs of sugar dependence in rats, e.g., indices of bingeing, withdrawal, increased intake after abstinence (deprivation effect), cross-sensitization with amphetamine, and increases in dopamine release in the nucleus accumbens due to repeated bingeing.

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1999Well-being : the foundations of hedonic psychology 1998Drug-activation of brain reward pathways

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2009Baclofen suppresses binge eating of pure fat but not a sugar-rich or sweet–fat diet

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