A fluoxetine-induced frontal lobe syndrome in an obsessive compulsive patient.

Rudolph Hoehn-Saric · Gordon J. Harris · Godfrey D. Pearlson · Christiane Cox · Steven R. Machlin · Edwaldo E. Camargo

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Obsessive-Compulsive Spectrum Disorders Schizophrenia research and treatment Treatment of Major Depression

Abstract

The authors report the occurrence of apathy, indifference, inattention, and perseveration in an obsessive compulsive patient taking high doses of fluoxetine. These changes were associated with a decrease in cerebral blood flow in the frontal lobes and changes in neuropsychological tests generally associated with frontal lobe impairment. These clinical manifestations disappeared 4 weeks after discontinuation of fluoxetine.

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