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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework · Study

ReviewLessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

David R. Cook2014

Review2014

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

David R. Cook · Dearg S. Brown · Robert Alexander · Ruth E. March · Paul Morgan · Gemma Satterthwaite +1 more

1,344 citations·0/0 files stored·Nature Reviews Drug Discovery

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Pharmaceutical Economics and Policy Computational Drug Discovery Methods Pharmaceutical industry and healthcare

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References

2004Can the pharmaceutical industry reduce attrition rates?2010How to improve R&D productivity: the pharmaceutical industry's grand challenge 2012Diagnosing the decline in pharmaceutical R&D efficiency

Cited by

2021A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions 2016Changing R&D models in research-based pharmaceutical companies 2016When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis 2021Approval success rates of drug candidates based on target, action, modality, application, and their combinations 2016Opportunities and Challenges for Drug Development: Public–Private Partnerships, Adaptive Designs and Big Data 2021Trials and Terminations: Learning from Competitors’ R&D Failures 2014A decade of innovation in pharmaceutical R&D: the Chorus model 2021Achieving end-to-end success in the clinic: Pfizer’s learnings on R&D productivity

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2016Changing R&D models in research-based pharmaceutical companiesreview · 3 shared references 2017Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indicationsreview · 3 shared references 2021Approval success rates of drug candidates based on target, action, modality, application, and their combinationsarticle · 3 shared references 2017The academic–industrial complex: navigating the translational and cultural dividereview · 3 shared references 2012Diagnosing the decline in pharmaceutical R&D efficiencyreview · 2 shared references 2012Drug discovery in pharmaceutical industry: productivity challenges and trendsarticle · 2 shared references

Details

Year2014

Typereview

Published2014-05-16

VenueNature Reviews Drug Discovery

ISSN-L1474-1776

Languageen

Citations1,344

Files0 public / 0

ShelfPharmaceutical Economics and Policy

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doi10.1038/nrd4309

openalex_workW1967105697

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