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Obsessive-Compulsive Disorder, Factor-Analyzed Symptom Dimensions and Serotonin Transporter Polymorphism

Se Joo Kim · Hong Shick Lee · Chan‐Hyung Kim

62 citations0/0 files storedNeuropsychobiology

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Obsessive-Compulsive Spectrum Disorders Neurotransmitter Receptor Influence on Behavior Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Abstract

Recently, on the basis of the effects of serotonin (5-HT) reuptake inhibitors in obsessive-compulsive disorder (OCD) treatment, several candidate genes related to 5-HT regulation have been hypothesized to play an important role in the development of OCD. One of them is 5-HT transporter gene. Therefore, the aims of this study were to investigate the associations between 5-HT transporter polymorphism and OCD. One hundred and twenty-four OCD patients and 171 normal controls participated in this study. Genomic DNA was extracted from their blood. Comparison of the genotypes and allele frequencies of the SERTPR polymorphism between the OCD group and the control group was made. Using principal component analysis, we derived four factors from thirteen main contents of the Y-BOCS checklist and investigated the association between these four factors and the SERTPR polymorphism. In this case-control study, we could not find any associations between the SERTPR polymorphism and the development of OCD. In the OCD group, patients with the L genotype had higher scores for the religious/somatic factor than with the S genotype. In conclusion, the SERTPR polymorphism does not affect the development of OCD. But SERTPR polymorphisms affect certain factors of OC symptoms. Moreover, the factor analytic approach used in the present study has identified meaningful symptom dimensions to help guide future research.

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References

1967Development of a Rating Scale for Primary Depressive Illness 1989The Yale-Brown Obsessive Compulsive Scale 1989The Yale-Brown Obsessive Compulsive Scale 1994The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency 1995A family study of obsessive-compulsive disorder 1997Symptoms of obsessive-compulsive disorder 1999Use of Factor-Analyzed Symptom Dimensions to Predict Outcome With Serotonin Reuptake Inhibitors and Placebo in the Treatment of Obsessive-Compulsive Disorder 1994Factor analysis of symptom subtypes of obsessive compulsive disorder and their relation to personality and tic disorders.

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2014Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective 2008Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder 2017Cross‐Cultural Phenomenology of Obsessive‐Compulsive Disorder 2008Association study between obsessive–compulsive disorder and serotonergic candidate genes

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