In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subjects with combat‐related posttraumatic stress disorder

Thomas W. Freeman · D A Cardwell · Craig N. Karson · Richard A. Komoroski

131 citations0/0 files storedMagnetic Resonance in Medicine

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Posttraumatic Stress Disorder Research Advanced MRI Techniques and Applications Traumatic Brain Injury Research

Abstract

Recent findings using volumetric MRI techniques have revealed that patients with combat-related and noncombat-related posttraumatic stress disorder (PTSD) have reductions in right hippocampal volume. Twenty-one veterans with PTSD and eight age-matched control veterans were studied using proton magnetic resonance spectroscopy to test the hypothesis that the N-acetyl-L-aspartic acid/creatine (NAA/Cr) ratio would be decreased in the right medial temporal lobe structures of patients with PTSD compared to controls. Patients with PTSD displayed significantly lower NAA/Cr ratio for the right medial temporal lobe relative to the left (P < or = 0.011). Patients with PTSD also had lower NAA/Cr in right medial temporal lobe (P < or = 0.013) and lower choline/Cr in left medial temporal lobe (P < or = 0.030) compared to control subjects. Because NAA is regarded as an indicator of neuronal density, this finding suggests that the neuronal density of right-sided medial temporal structures in patients with combat-related PTSD may be decreased.

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References

1994DSM-IV: Diagnostic and Statistical Manual of Mental Disorders 1995MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder 1997Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report 1996A Symptom Provocation Study of Posttraumatic Stress Disorder Using Positron Emission Tomography and Script-Driven Imagery 1996Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder

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