Article1996

Oxytocin and oxytocin‐analogue F314 inhibit cell proliferation and tumor growth of rat and mouse mammary carcinomas

Paola Cassoni · Anna Sapino · Mauro Giulio Papotti · Gianni Bussolati

52 citations0/0 files storedInternational Journal of Cancer

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Neuroendocrine regulation and behavior Estrogen and related hormone effects Growth Hormone and Insulin-like Growth Factors

Abstract

The effects of oxytocin (OT) and the OT-analogue F314 were investigated an xenografts of mouse mammary and colon carcinomas (TS/A and C26 tumors) and of rat mammary carcinoma (D-R3230AC). In all cases, proliferation was previously assessed by cell counting in cultured cell lines, whereas tumor growth was checked by serial measures of tumor volume and by evaluation of tumor weight at the end of the experiment. Both cell proliferation and tumor growth were inhibited by OT and F314. These data support previous observations on the inhibitory effect of OT and F314 on the growth of MCF7, T47D and MDA-MB231 human breast cancer cell lines and open new prospects for testing the effect of this hypothalamic hormone and its analogues on the control of breast carcinoma growth.

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1992Structure and expression of a human oxytocin receptor 1995Structure, characterization, and expression of the rat oxytocin receptor gene.1994Oxytocin inhibits proliferation of human breast cancer cell lines 1993Oxytocin enhances myoepithelial cell differentiation and proliferation in the mouse mammary gland 1993Expression and localization of oxytocin receptor gene in human uterine endometrium in relation to the menstrual cycle 1993Oxytocin receptor subtypes in the pregnant rat myometrium and decidua: pharmacological differentiations 1992Activity of oxytocinergic neurons in the paraventricular nucleus mirrors the periodicity of the endogenous stimulatory rhythm regulating prolactin secretion

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