Articlehybrid1996

Fluoxetine Treatment of Children with Selective Mutism: An Open Trial

Eldon S. Dummit · RACHEL G. KLEIN · BARBARA ASCHE · Jacqueline L. Martin · NANCY K. TANCER

188 citations0/0 files storedJournal of the American Academy of Child & Adolescent Psychiatry

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Treatment of Major Depression

Abstract

OBJECTIVE: A pilot study was designed to evaluate the safety and efficacy of fluoxetine treatment for children with selective mutism (elective mutism in DSM-III-R). METHOD: Twenty-one children (mean age 8.2 years, range 5 through 14) participated in a 9-week open trial of fluoxetine in graduated doses (mean end dose 28.1 mg, range 10 to 60 mg) with systematic baseline and outcome evaluations and weekly clinical assessment. RESULTS: All 21 children met DSM-III-R and DSM-IV criteria for anxiety disorders. After fluoxetine treatment, 76% were improved, with diminished anxiety and increased speech in public settings, including school. Improvement at week 9 was inversely correlated with age. CONCLUSIONS: Persistent selective mutism presenting with comorbid anxiety disorders may respond to fluoxetine treatment.

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References

1967Comprehensive Textbook of Psychiatry 1983A Children's Global Assessment Scale (CGAS)1969Measurement of social-evaluative anxiety.2015Social Phobia 1981Rating scales to assess depression in school-aged children.1979Advances in Clinical Child Psychology 1978Normative data on Revised Conners Parent and Teacher Rating Scales 1994Comprehensive Textbook of Psychiatry

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2008Selective mutism: A review and integration of the last 15 years 1997Systematic Assessment of 50 Children With Selective Mutism 2006Practitioner Review: Psychosocial interventions for children with selective mutism: a critical evaluation of the literature from 1990–2005 2015Children Who are Anxious in Silence: A Review on Selective Mutism, the New Anxiety Disorder in DSM-5 1997Practice Parameters for the Assessment and Treatment of Children and Adolescents with Anxiety Disorders 2005A long‐term outcome study of selective mutism in childhood

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