Article2006

Features Associated With Laxative Abuse in Individuals With Eating Disorders

Federica Tozzi · Laura Marie Thornton · James Earl Mitchell · Manfred Maximilian Fichter · Kelly L. Klump · Lisa Lilenfeld +4 more

116 citations0/0 files storedPsychosomatic Medicine

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Eating Disorders and Behaviors Nutrition, Health and Food Behavior Personality Disorders and Psychopathology

Abstract

Objective: Laxative abuse is common in patients with anorexia and bulimia nervosa and has been associated with longer duration of illness, suicide attempts, impulsivity, and greater eating and general psychopathology. We explored the extent to which laxative abuse was associated with specific psychopathological features across eating disorder subtypes. Methods: Participants were 1021 individuals from the multisite, International Price Foundation Genetic Studies. Axis I disorders, personality disorders and traits, and obsessive compulsive features were assessed. Results: Laxative abuse was associated with worse eating disorder and general psychopathology and higher prevalence of borderline personality disorder (BPD). Symptom level analyses revealed that specific features of BPD, including suicidality and self-harm, feelings of emptiness, and anger, were most strongly associated with laxative abuse. Conclusions: The function of laxative abuse may differ across individuals with eating disorders, alternatively serving as a method of purging and a form of self-harm. ED = eating disorder; AN = anorexia nervosa; BN = bulimia nervosa; PAN = purging anorexia nervosa; BAN = binge-purge anorexia nervosa; PBN = purging bulimia nervosa; EDNOS = eating disorders not otherwise specified; ANBN = individuals with both a history of anorexia and bulimia nervosa; BPD = borderline personality disorder; PTSD = posttraumatic stress disorder; BMI = body mass index; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; SCID-I and -II = Structured Clinical Interview for DSM-IV for Axis I and Axis II disorders; SIAB = Structured Inventory of Anorexia Nervosa and Bulimic Syndromes; TCI = Temperament and Character Inventory; MPS = Multidimensional Perfectionism Scale; YBOCS = Yale-Brown Obsessive Compulsive Scale; YBC-EDS = Yale-Brown-Cornell Eating Disorder Scale; GEE = generalized estimating equations.

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References

1970Manual for the State-Trait Anxiety Inventory 1989The Yale-Brown Obsessive Compulsive Scale 1993A Psychobiological Model of Temperament and Character 1990The dimensions of perfectionism 1997Structured clinical interview for DSM-IV axis II personality disorders : SCID-II 1970STAI manual for the State-trait anxiety inventory 1979Anorexia Nervosa 1998Self-mutilation in clinical and general population samples: Prevalence, correlates, and functions.

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2010Habitual starvation and provocative behaviors: Two potential routes to extreme suicidal behavior in anorexia nervosa 2008Suicide attempts in bulimia nervosa: Personality and psychopathological correlates 2016Associations between eating disorder symptoms and suicidal ideation through thwarted belongingness and perceived burdensomeness among eating disorder patients 2018Factorial integrity and validation of the Eating Pathology Symptoms Inventory (EPSI)

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