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A cross-sectional study was conducted to determine the seroprevalence of major transfusion-transmissible infections among blood donors at Felege Hiwot referral hospital, northwest Ethiopia.The overall seroprevalence of major bloodborne pathogens among blood donors was 43.2%, of which HBsAg, anti-HCV IgG, HIV seropositivity and syphilis accounted for 25%, 13.3%, 11.7% and 1.2% respectively.Crude seroprevalence of major blood born pathogens was significantly higher in commercial blood donors (56.6%) compared to voluntary (17.6%) and replacement blood donors (53.6%) (p=0.0001).[Ethiop.
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