Dopamine beta‐hydroxylase (DBH) activity and ‐1021C/T polymorphism of DBH gene in combat‐related post‐traumatic stress disorder

Maja Mustapić · Nela Pivac · Dragica Kozarić‐Kovačić · Martina Deželjin · Joseph F. Cubells · Dorotea Mück‐Šeler

67 citations0/0 files storedAmerican Journal of Medical Genetics Part B Neuropsychiatric Genetics

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Posttraumatic Stress Disorder Research Neurotransmitter Receptor Influence on Behavior Stress Responses and Cortisol

Abstract

The roles of dopamine (DA) and norepinephrine (NE) in posttraumatic stress disorder (PTSD) are unclear. The aim of the study was to determine plasma dopamine beta-hydroxylase (DBH) activity and DBH-1021C/T gene polymorphism in combat veterans with (N = 133) or without (N = 34) chronic PTSD. Similar frequencies in genotype or allele distribution were found between veterans with or without PTSD. War veterans with PTSD had lower DBH activity, associated with the DBH-1021C/T variant in DBH genes, than veterans without PTSD. A significantly lower plasma DBH activity was found in combat veterans with PTSD carrying the CC genotype as compared to veterans without PTSD carrying the corresponding genotype. Since both groups were exposed to the same trauma, it is possible that a pre-existing trait difference in regulation of NE function contributed to a differential vulnerability to develop PTSD, or that the regulation of DBH expression was different in response to trauma. The results suggest that that genotype-controlled measurement of plasma DBH activity might be used as a potential biological marker of the response to trauma, and that further studies of DBH and other loci related to DA and NA in PTSD are warranted.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 67 citations exist upstream.

References

1960A RATING SCALE FOR DEPRESSION 1995The development of a Clinician-Administered PTSD Scale 2001Handbook of Psychiatric Measures 2005Posttraumatic stress disorder: A state-of-the-science review 1999Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder 1995Nocturnal/daytime urine noradrenergic measures and sleep in combat-related PTSD 1998Plasma norepinephrine and 3-methoxy-4-hydroxyphenylglycol concentrations and severity of depression in combat posttraumatic stress disorder and major depressive disorder 1993Elevated plasma dopamine in posttraumatic stress disorder: A preliminary report

Cited by

2010Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability 2020Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD 2016The Association Between Genetic Variants in the Dopaminergic System and Posttraumatic Stress Disorder

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.