Reproducibility of clinical data I: continuous outcomes

Abstract

Abstract Across a variety of clinical settings, repeated measurements on an individual, obtained under identical circumstances, often differ from one another. This implies the measurements lack perfect reproducibility. Topics related to reproducibility of clinical measurements are introduced in this paper. In this first of two parts, continuous outcomes are addressed. The intraclass correlation coefficient, ρ, has been the traditional coefficient of reproducibility for continuous outcomes. The importance of ρ regarding observations on an individual, and observations among populations, is outlined. Estimation and inferential procedures for ρ are reviewed and worked examples are provided. Copyright © 2004 John Wiley & Sons, Ltd.

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