Article2003

Effects of Gabapentin on Anxiety Induced by Simulated Public Speaking

João Quevedo · Tatiana Barichello · Iván Izquierdo · Mônica Ryff Moreira Roca Vianna · Fernanda de Paris · João Vicente Busnello +2 more

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Treatment of Major Depression Communication in Education and Healthcare

Abstract

The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated. Thirty-two normal male volunteers (aged 17-30 years) had their anxiety and mood evaluated by self-scales [Visual Analogue Mood Scale (VAMS) and Profile of Mood State (POMS)] during the SPS procedure. Physiological measures (heart rate and blood pressure) were taken. Treatment with gabapentin at 800 mg attenuated the anxiety of subjects that had a decrease on the VAMS item calm-excite. In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin.

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1974The use of analogue scales in rating subjective feelings 2000Placebo-Controlled Study of Gabapentin Treatment of Panic Disorder 1998Gabapentin as a Potential Treatment for Anxiety Disorders 1982Simulated public speaking as a model of clinical anxiety 1994Flumazenil has an anxiolytic effect in simulated stress

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