The isolation, identification and properties of the hormonal granules of the neurohypophysis

R. Barer · H. Heller · Karl P. Lederis

100 citations0/0 files storedProceedings of the Royal Society B Biological Sciences

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Neuroendocrine regulation and behavior Neuropeptides and Animal Physiology Cellular transport and secretion

Abstract

Abstract Methods for the preparation of cell fractions from homogenates of the posterior pituitary glands of rabbits are described. By controlling the speed of centrifugation it was possible to isolate 80% of the oxytocin and vasopressin in a sedimentable form and about half of the total hormones or two-thirds of the sedimentable hormones in a single fraction. Electron microscopy of this fraction showed that it was composed mainly of membrane-bounded granules about 1300 Å in diameter. Similar granules were found in the neural swellings of the rabbit neurohypophysis studied by electron microscopy. The possibility that vasopressin and oxytocin are stored in different granules is discussed.

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References

1957Elektronenmikroskopische Beobachtungen an der Neurohypophyse

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1964Fine structure and hormone content of the hypothalamo-neurohypophysial system of the rainbow trout (Salmo irideus) exposed to sea water 1966Release of vasopressin and oxytocin from isolated pituitary glands of adult and new‐born rats 1967The isolation of purified neurosecretory granules from bovine pituitary posterior lobes. Comparison of granule protein constituents with those of neurophysin 1975THE ROLE OF NEUROPHYSIN PROTEINS: SUGGESTIONS FROM THE STUDY OF THEIR TRANSPORT AND TURNOVER*1968The isolation of neurophysin-I and -II from bovine pituitary neurosecretory granules separated on a large scale from other subcellular organelles. Demonstration of slow equilibration of neurosecretory granules during centrifugation in a sucrose density gradient 1973An ultrastructural study of the effects of hypophysectomy on the supraoptic nucleus of the rat 1969�ber die Ultrastruktur neurosekretorischer Elementargranula

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