Article2004

Corticotropin-Releasing Factor Inhibits Maternal Aggression in Mice.

Stephen C. Gammie · Alejandro Negrón · Sarah M. Newman · Justin S. Rhodes

145 citations0/0 files storedBehavioral Neuroscience

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Neuroendocrine regulation and behavior Neuropeptides and Animal Physiology Stress Responses and Cortisol

Abstract

Lactating females that fiercely protect offspring exhibit decreased fear and anxiety. The authors tested whether decreased corticotropin-releasing factor (CRF), an activator of fear and anxiety, plays a functional role in maternal aggression. Intracerebroventricular (icv) injections of CRF (1.0 and 0.2 microg, but not 0.02 microg) significantly inhibited maternal aggression but not other maternal behaviors. The CRF antagonist D-Phe-CRF(12-41) had no effect. Maternal aggression and icv CRF (0.2 microg) induced Fos in 11 of the same regions, including the lateral and medial septum, the bed nucleus of the stria terminalis, the medial and central amygdala, the periaqueductal gray, the dorsal raphe, and the locus coeruleus. These findings suggest that decreased CRF is necessary for maternal aggression and may act by altering brain activity in response to an intruder.

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References

1999Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats 2002Sensory, hormonal, and neural control of maternal aggression in laboratory rodents 1991Mammalian parenting; biochemical, neurobiological and behavioral determinants 1990Mammalian parenting: biochemical, neurobiological, and behavioral determinants 1997Role of the Midbrain Periaqueductal Gray in Maternal Nurturance and Aggression: c-fos and Electrolytic Lesion Studies in Lactating Rats

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