Reduced Caudate Nucleus Volume in Obsessive-compulsive Disorder

Delbert G. Robinson

320 citations0/0 files storedArchives of General Psychiatry

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Obsessive-Compulsive Spectrum Disorders Neural and Behavioral Psychology Studies Neurological disorders and treatments

Abstract

BACKGROUND: Current hypotheses about the neuroanatomical structures involved in obsessive-compulsive disorder (OCD) suggest abnormalities in cortical-striatal-thalamic-cortical circuits. This study examined selected brain regions within or adjacent to these circuits. METHODS: Magnetic resonance imaging scans from 26 patients with OCD and 26 healthy controls were analyzed to determine the volumes of the following structures: prefrontal cortex (cortex anterior to the genu of the corpus callosum), caudate nucleus, lateral and third ventricles, and whole brain. RESULTS: Patients with OCD had significantly smaller caudate nucleus volumes than controls (F[1,48] = 9.4, P = .004) but did not differ in prefrontal cortex size or in volumes of the lateral or third ventricles. Structural volumes were not significantly correlated with the duration or severity of OCD symptoms. CONCLUSION: Our findings provide additional evidence for pathological involvement of the caudate in OCD.

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References

1987Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder 1989Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder 1988Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder 1992Toward a Neuroanatomy of Obsessive-Compulsive Disorder 1989Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive- compulsive disorder 1989Cerebral glucose metabolic rates in obsessive compulsive disorder

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