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The NIH Toolbox for Assessment of Neurological and Behavioral Function is a five- year project to identify, create and validate brief comprehensive assessment tools to measure outcomes in longitudinal, epidemiological and intervention studies across the life span in the areas of cognition, emotion, motor and sensory function. The project is one of the initiatives in the NIH Blueprint for Neuroscience Research. This presentation will provide an update on its progress with emphasis on its adaptability and accessibility for use with diverse groups. While many epidemiological studies collect information on cognition and emotion as well as motor and sensory function, there is little consistency in actual measures used across studies. As a result, between study comparisons and data pooling is difficult if not impossible. Common, validated measures of these indicators of neural and behavioral health could then be used as a form of “common currency” across study designs and populations. This would maximize yield from these large and expensive studies with minimal increase in subject burden and cost. The NIH Toolbox construction is in two phases. Phase 1, now almost completed, included domain and sub-domain selection, instrument selection, and instrument development, including refining and calibrating where needed. Phase 2 will include instrument validation as well as a study of a large random sample of the general community dwelling population. As part of Phase 1, the selected instruments were reviewed by expert teams to ensure acceptability by individuals at different age groups from children to the elderly as well as by the handicapped. The NIH Toolbox will provide an opportunity to consistently measure cognition, emotion, motor and sensory function over the life span. As diseases of the elderly frequently have their genesis much earlier in life, this may provide a way to identify the early indicators and risk factors for these diseases.
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