Genetics of personality disorders: Perspectives from personality and psychopathology research.

Joel T. Nigg · H. Hill Goldsmith

138 citations0/0 files storedPsychological Bulletin

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Personality Disorders and Psychopathology Schizophrenia research and treatment Personality Traits and Psychology

Abstract

Although the field is young, studies pertinent to genetic hypotheses have accumulated for several personality disorders. Genetic links to personality disorders from the domains of normal personality and Axis I disorders are reviewed. Evidence of a link to schizophrenia is clearest for schizotypal and less conclusive for paranoid and schizoid personality disorders. A genetic association between borderline personality disorder and affective disorders has not been clearly supported, but there may be a subtype genetically linked to affective disorders. Evidence of genetic influence is mixed for obsessive-compulsive personality disorder. In general, greater attention to dimensional phenotypic measures and multivariate designs can yield more definitive answers regarding the correct subtyping and probable etiology of personality disorders.

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References

2013Diagnostic and Statistical Manual of Mental Disorders 1969Attachment and Loss 1978Patterns of Attachment: A Psychological Study of the Strange Situation 1972Attachment and Loss. Vol. 1. Attachment 1981Diagnostic and Statistical Manual of Mental Disorders, 3rd ed 1978Research Diagnostic Criteria 1990Personality Structure: Emergence of the Five-Factor Model 1972Diagnostic Criteria for Use in Psychiatric Research

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