Default mode network subsystem alterations in obsessive–compulsive disorder

Jan Carl Beucke · Jorge Sepulcre · Mark C. Eldaief · Miriam Sebold · Norbert Kathmann · Christian Kaufmann

112 citations0/0 files storedThe British Journal of Psychiatry

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Obsessive-Compulsive Spectrum Disorders Neural and Behavioral Psychology Studies Functional Brain Connectivity Studies

Abstract

BACKGROUND: Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results. AIMS: To resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD. METHOD: Comparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging. RESULTS: Significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed. CONCLUSIONS: Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.

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References

2013Diagnostic and Statistical Manual of Mental Disorders 1961An Inventory for Measuring Depression 1970Manual for the State-Trait Anxiety Inventory 1979A New Depression Scale Designed to be Sensitive to Change 1989The Yale-Brown Obsessive Compulsive Scale 2002The Obsessive-Compulsive Inventory: Development and validation of a short version.1985Obsessional-compulsive problems: A cognitive-behavioural analysis 2007Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited

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2022Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis 2016Increased functional connectivity between the default mode and salience networks in unmedicated adults with obsessive-compulsive disorder 2017Altered connectivity within and between the default mode, central executive, and salience networks in obsessive-compulsive disorder 2019Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

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