Neurobiological aspects of PTSD: Review of clinical and preclinical studies

John Harrison Krystal · Thomas R. Kosten · Steven Mark Southwick · John W Mason · Bruce D. Perry · Earl L. Giller

121 citations0/0 files storedBehavior Therapy

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Posttraumatic Stress Disorder Research Psychoanalysis and Psychopathology Research Stress Responses and Cortisol

Abstract

Although physiologic studies of post-traumatic stress disorder (PTSD) date to World War I, clinical neuroscience has only recently explored biological mechanisms involved in this disorder. This review will selectively consider clinical and preclinical studies pertaining to biological theories and pharmacological treatments for PTSD, highlighting the role of central noradrenergic systems in its pathophysiology.

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References

1987Psychophysiologic Assessment of Posttraumatic Stress Disorder Imagery in Vietnam Combat Veterans 1986Urinary Free-Cortisol Levels in Posttraumatic Stress Disorder Patients 1985Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress 1978Trauma and Affects 1987Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder 1982A psychophysiological study of Post Traumatic Stress Disorder in Vietnam veterans 1983Validation of a multimethod assessment of posttraumatic stress disorders in Vietnam veterans.1984Post-traumatic stress disorder : psychological and biological sequelae

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1991The biological response to psychic trauma: Mechanisms and treatment of intrusion and numbing 1994Pharmacotherapy for Post-Traumatic Stress Disorder 1995Memory, attention, and executive deficits in POW survivors: Contributing biological and psychological factors.1999Posttraumatic Stress Disorder in the Elderly: A Review 2001The psychobiology and psychopharmacology of PTSD

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