Bilberry extract supplementation for preventing eye fatigue in video display terminal workers

Yoko Ozawa · Motoko Kawashima · S. Inoue · E. Inagaki · Atsushi Suzuki · Emi Ooe +2 more

63 citations0/0 files storedThe journal of nutrition health & aging

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Ergonomics and Musculoskeletal Disorders Retinal Diseases and Treatments Ocular Surface and Contact Lens

Abstract

OBJECTIVES: To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads. DESIGN AND SETTING: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan. PARTICIPANTS: Two hundred eighty-one office workers aged 20-40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA). INTERVENTION: The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks. MEASUREMENTS: The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo. RESULTS: Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10-1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group. CONCLUSIONS: BE supplementation improved some of the objective and subjective parameters of eye fatigue induced by VDT loads.

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1993Dry Eyes and Video Display Terminals 1985Work with video display terminals among office employees. I. Subjective symptoms and discomfort.1998Eye problems and visual display terminals--the facts and the fallacies 2013An Internet-Based Intervention to Promote Mental Fitness for Mildly Depressed Adults: Randomized Controlled Trial 2000Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans.2007The Influence of Visual Display Terminal Use on the Physical and Mental Conditions of Administrative Staff in Japan 1994Physiological Indices of Visual Fatigue due to VDT Operation: Pupillary Reflexes and Accommodative Responses.1996Accumulation of VDT Work-Related Visual Fatigue Assessed by Visual Evoked Potential, Near Point Distance and Critical Flicker Fusion.

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