Monoamine Metabolites in CSF and Suicidal Behavior

Lil Träskman

689 citations0/0 files storedArchives of General Psychiatry

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Suicide and Self-Harm Studies Treatment of Major Depression Tryptophan and brain disorders

Abstract

Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 689 citations exist upstream.

References

1979A New Depression Scale Designed to be Sensitive to Change 19765-HIAA in the Cerebrospinal Fluid 1978A COMPREHENSIVE PSYCHOPATHOLOGICAL RATING SCALE 1974A Hundred Cases of Suicide: Clinical Aspects

Cited by

1990Emergence of intense suicidal preoccupation during fluoxetine treatment 1998The neurobiology of suicide 1995Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims 1990Autoradiographic Demonstration of Increased Serotonin 5-HT2 and β-Adrenergic Receptor Binding Sites in the Brain of Suicide Victims 1990Cerebrospinal Fluid Monoamine Metabolites, Aggression, and Impulsivity in Disruptive Behavior Disorders of Children and Adolescents 2010Method of attempted suicide as predictor of subsequent successful suicide: national long term cohort study 1987Cerebrospinal Fluid Monoamine Metabolite Levels in Male Arsonists 2008Use of doping agents, particularly anabolic steroids, in sports and society

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.