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Purpose The purpose of this research paper is to study the enablers of Six Sigma and to establish relationship among them using interpretive structural modeling (ISM). Design/methodology/approach The research paper presents a blend of theoretical framework and practical applications. In the paper, 11 enablers of Six Sigma are identified from literature survey and experts' opinion and then these are validated by questionnaire survey in India. Finally, ISM is used to obtain structural relationship among these enablers of Six Sigma. Findings The ISM‐based model indicates that “effective top management leadership role”, “availability of funds” and “availability of expert training” are strategic requirements; “organizational culture”, “organizational infrastructure”, “quality maturity level of organization”, and “employees' adaptability and flexibility towards learning” are tactical requirements. “Statistical thinking”, “committed work force”, “reliable data gathering and retrieval system”, and “technical competence” are operational requirements for Six Sigma applications. Originality/value Enablers are the building blocks for deployment of Six Sigma. To know the key enablers and relationship among them can help many organizations to develop Six Sigma competences. It is one of the foremost attempts to model enablers of Six Sigma. The paper provides useful insights to the Six Sigma implementers, consultants, and researchers.
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