Auditory brainstem projections to the ferret superior colliculus: Anatomical contribution to the neural coding of sound azimuth

Andrew J. King · Ze Dong Jiang · David R. Moore

92 citations0/0 files storedThe Journal of Comparative Neurology

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Multisensory perception and integration Hearing, Cochlea, Tinnitus, Genetics Neuroscience and Music Perception

Abstract

The mammalian superior colliculus (SC) contains a neural map of auditory space. It is not known whether this topographic representation emerges at the level of the SC or is relayed there from other auditory areas. We have used retrograde labelling techniques in ferrets to examine the sources and pattern of innervation from auditory brainstem nuclei. After multiple injections of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) into the SC, the heaviest concentrations of labelled cells were found in the nucleus of the brachium (BIN) and external nucleus of the inferior colliculus, with much weaker labelling in the nucleus sagulum, dorsal, intermediate and ventral nuclei of the lateral lemniscus, paralemniscal regions, and periolivary nuclei. The projections were predominantly ipsilateral, although labelled cells were found on both sides of the brainstem. Single injections of WGA-HRP or discrete injections of red and green latex microspheres revealed that the caudal and lateral regions of the SC receive the heaviest projections, although the majority of the retrogradely labelled neurons in the contralateral BIN project to rostral SC. On the ipsilateral side, neurons in rostral and caudal regions of the BIN were labelled primarily by the tracer injected into rostral and caudal regions of the SC, respectively. However, no clear segregation was apparent in the BIN after injections into the medial and lateral regions or in any of the other nuclei after either injection paradigm. These data suggest that converging inputs from several auditory brainstem nuclei contribute to the construction of the auditory space map in the SC, although information about sound azimuth may be conveyed to this nucleus via a spatially ordered projection from the ipsilateral BIN.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 92 citations exist upstream.

References

1979Sources of subcortical projections to the superior colliculus in the cat 1982Auditory and visual maps of space in the optic tectum of the owl 1984A neural code for auditory space in the cat's superior colliculus 1985Integration of visual and auditory information in bimodal neurones in the guinea-pig superior colliculus 1983Cells responsive to free‐field auditory stimuli in guinea‐pig superior colliculus: distribution and response properties.1981The representation of the auditory and somatosensory systems in the external nucleus of the cat inferior colliculus 1992Inferior and Superior Colliculi 1987Spatial response properties of acoustically responsive neurons in the superior colliculus of the ferret: a map of auditory space

Cited by

1998Signals from the Superficial Layers of the Superior Colliculus Enable the Development of the Auditory Space Map in the Deeper Layers 2000Topographical projection from the superior colliculus to the nucleus of the brachium of the inferior colliculus in the ferret: convergence of visual and auditory information 1999Sensory experience and the formation of a computational map of auditory space in the brain

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.