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To the Editor: In 1988, the Global Polio Eradication Initiative was formed, with the aim of reducing infection with poliomyelitis virus.Two decades later in 2008, a total of 1,625 children contracted acute flaccid paralysis caused by poliovirus infection (1).This finding represented a 150% increase over the number of cases in 2007 (1) and resulted in the reemergence of polio as one of the world's deadliest infections.As of 2009, polio remains endemic to 4 countries (India, Nigeria, Pakistan, and Afghanistan); in 2008, cases were also detected in 14 other countries.Religious opposition by Muslim fundamentalists is a major factor in the failure of immunization programs against polio in Nigeria (2), Pakistan (3) and Afghanistan (4).This religious conflict in the tribal areas of Pakistan is one of the biggest hindrances to effective polio vaccination.Epidemiologists have detected transmission of wild poliovirus from polio-endemic districts in Afghanistan, most of which are located in the southern region of this country bordering Pakistan, to tribal areas of Pakistan (4).This transmission has resulted in new cases of polio in previously polio-free districts.The local Taliban have issued fatwas denouncing vaccination as an American ploy to sterilize Muslim populations.Another common superstition spread by extremists is that vaccination is an attempt to avert the will of Allah.The Taliban have assassinated vaccination officials, including Abdul Ghani Marwat, who was the head of the government's vaccination campaign in Bajaur Agency in the Pakistani tribal areas, on his way back from meeting a religious cleric (5).Over the past year, several kidnappings and beatings of vaccinators have been reported.Vaccination campaigns
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