The reproductive option of sex selection

Abstract

One reproductive option that has long been unrealized is that of choosing the sex of one's child. This is not for lack of ideas; historically there having been many unproved methods, many fanciful and most now abandoned (Carson, 1988). Conceptions occurring two or three days after ovulation have a slightly increased likelihood of being male, but perhaps only in certain circumstances; at any rate, this observation has little practical value (Gray et al., 1998). Biological based methods have not previously succeeded. Now, Fugger et al. have reported that separation into X- or Y-bearing spermatozoa may be efficacious (Fugger et al., 1998). Genetic indications for sperm separation are unassailable, and surely few could disagree that selecting a child of a given sex can avoid certain birth defects. Specifically, female infants would not ordinarily be affected with an X-linked recessive disorder; male infants could not inherit an X-linked dominant gene from their affected father, whereas half their sisters would.

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