The genesis of Edward Jenner's Inquiry of 1798: A comparison of the two unpublished manuscripts and the published version

Abstract

continues to be a controversial figure in medical history and his role in the introduction of smallpox vaccination is still debated.Those interested in the development of Jenner's ideas on smallpox prophylaxis will know that two manuscripts exist which contain much of what was to be incorporated into his famous monograph, privately published in 1798.1One manuscript (here designated RC-MS), in the possession of the Royal College of Surgeons of England, was compared to the published Inquiry by E. M. Crookshank,2 and the text was later published to commemorate the centenary of Jenner's death.3Unfortunately, both these analyses omit note of virtually all the important features that make them of value to those interested in the development of Jenner's ideas.

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