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We discuss the specific features of the paradigm shift of Russian regional science, focusing on the organization of basic research on spatial development in the context of global and national challenges. A summary assessment is made of the main results of the 2009–2011 pioneering program carried out by institutes of the Russian Academy of Sciences: “Fundamental Problems of the Spatial Development of the Russian Federation: An Interdisciplinary Synthesis.” The objectives of the new wave of breakthrough research within the 2012–2014 program “Role of Space in the Modernization of Russia: Natural and Socioeconomic Potential” are described.
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