Article1995

From Science to Practice

108 citations0/0 files storedJAMA

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Meta-analysis and systematic reviews Clinical practice guidelines implementation Delphi Technique in Research

Abstract

In this issue ofTHE JOURNAL, Jeng et al1report discrepancies between the results of meta-analyses using aggregate data available from the literature (MAL) and meta-analyses using individual patient data (MAP). This may be seen as further grounds for mistrusting meta-analysis in general2,3and MAL in particular,4but before deciding that all meta-analyses are an exercise in "mega-silliness,"5consider the alternatives. See also p 830. The key characteristic of MAPs is the use of individual patient data (IPD). Meta-analyses using aggregate data also can, and frequently do, include unpublished data, so the termIPD meta-analysesis preferable to avoid confusing issues relating to using IPD and issues relating to using unpublished data. IPD meta-analyses require international cooperation between the individuals and groups who have conducted relevant trials and a considerable amount of time, personnel, and financial resources.6These global collaborative endeavors have yielded important information

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References

1995Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials 1992A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction 1992Factors Influencing Publication of Research Results 1993Meta-analysis of the literature or of individual patient data: is there a difference?1993The Cochrane Collaboration: Preparing, Maintaining, and Disseminating Systematic Reviews of the Effects of Health Care 1990Underreporting Research Is Scientific Misconduct 1995Misleading meta-analysis 1995Practical methodology of meta‐analyses (overviews) using updated individual patient data

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