Review2000

Anxiety disorders: a review of tricyclic antidepressants and selective serotonin reuptake inhibitors

218 citations0/0 files storedActa Psychiatrica Scandinavica

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Treatment of Major Depression Psychological Treatments and Disorders

Abstract

OBJECTIVE: Anxiety disorders are the most common mental health disorders. While the older tricylic antidepressants (TCAs) are efficacious in the treatment of many anxiety disorders, recent studies with fluoxetine and other selective serotonin reuptake inhibitors (SSRIs) have emphasized the role of serotonin in the aetiology of these conditions. METHOD: We reviewed the efficacy, safety and tolerability of TCAs and SSRIs in the treatment of the most common anxiety disorders, specifically, panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social phobia and generalized anxiety disorder. RESULTS: Both the TCA and SSRI antidepressants are effective in treating a wide variety of anxiety disorders. SSRIs, due to their greater safety and tolerability, should be the preferred choices in treating anxiety disorders in those instances where TCAs and SSRIs are considered equally effective. In the cases of OCD and social phobia, SSRIs are almost always preferable given that the TCAs do not appear effective in these disorders. CONCLUSION: Further research is needed on the naturalistic long-term use of the TCAs and SSRIs in the treatment of anxiety disorders.

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References

1994Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States 1995Posttraumatic Stress Disorder in the National Comorbidity Survey 2009Diagnostic and Statistical Manual of Mental Disorders 1988One-Month Prevalence of Mental Disorders in the United States 1988The Epidemiology of Obsessive-Compulsive Disorder in Five US Communities 1987Post-Traumatic Stress Disorder in the General Population 1992Social Phobia 1980Clomipramine Treatment of Obsessive-Compulsive Disorder

Cited by

2015Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches 2001Venlafaxine Extended Release (ER) in the Treatment of Generalised Anxiety Disorder 2003Escitalopram in the Treatment of Panic Disorder 2003Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive–compulsive disorder 2002Addition of cognitive‐behaviour therapy for obsessive‐compulsive disorder patients non‐responding to fluoxetine 2004

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