Cannabinoids: possible role in patho‐physiology and therapy of Gilles de la Tourette syndrome

Kirsten Müller‐Vahl · HANS KOLBE · Udo Schneider · Hinderk Meiners Emrich

108 citations0/0 files storedActa Psychiatrica Scandinavica

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Obsessive-Compulsive Spectrum Disorders Schizophrenia research and treatment Cannabis and Cannabinoid Research

Abstract

High densities of cannabinoid receptors were found in the basal ganglia and hippocampus, indicating a putative functional role of cannabinoids in movement and behaviour. Anecdotal reports suggested beneficial effects of marijuana in Tourette's syndrome (TS). We therefore interviewed 64 TS patients with regard to use of marijuana and its influence on TS symptomatology. Of 17 patients (27%) who reported prior use of marijuana, 14 subjects (82%) experienced a reduction or complete remission of motor and vocal tics and an amelioration of premonitory urges and obsessive-compulsive symptoms. Our results provide more evidence that marijuana improves tics and behavioural disorders in TS. It can be speculated that cannabinoids might act through specific receptors, and that the cannabinoid system might play a major role in TS pathology.

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References

1996Tourette Syndrome: Prediction of Phenotypic Variation in Monozygotic Twins by Caudate Nucleus D2 Receptor Binding 1995[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder

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2000Gilles de la Tourette Syndrome: symptomatic treatment based on evidence 2013Treatment of Tourette Syndrome with Cannabinoids 2009Cannabinoids for Tourette's Syndrome 2003Cannabinoids reduce symptoms of Tourette’s syndrome 2000Current issues in Tourette syndrome 2016Treatment-refractory Tourette Syndrome 2001Pharmacological Options for the Treatment of Tourette??s Disorder 2017Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome

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