Study on serum cytokine levels in posttraumatic stress disorder patients

Min Guo · Juncheng Guo · Xiangling Jiang · Feng Chen · Yunsuo Gao

113 citations0/0 files storedAsian Pacific Journal of Tropical Medicine

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Posttraumatic Stress Disorder Research Child Abuse and Trauma Stress Responses and Cortisol

Abstract

OBJECTIVE: To evaluate serum IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-α levels in posttraumatic stress disorder (PTSD) patients. METHODS: We utilized ELISA technology to examine cytokines such as IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-α in serum from 50 well-characterized individuals with a primary DSM-IV PTSD diagnosis, and 50 age- and gender-matched healthy controls. We conservatively employed a Mann-Whitney U testing. RESULTS: Individuals with primary PTSD had significantly elevated peripheral cytokine levels for all 6 different cytokines compared to age- and gender-matched healthy controls (all P<0.01). CONCLUSIONS: These findings suggest that a generalized inflammatory state may be present in individuals with PTSD.

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References

2011Differential immune system DNA methylation and cytokine regulation in post‐traumatic stress disorder 2011Glucocorticoid Receptor Pathway Components Predict Posttraumatic Stress Disorder Symptom Development: A Prospective Study

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2015Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression 2018A review on inflammatory cytokine-induced alterations of the brain as potential neural biomarkers in post-traumatic stress disorder 2017Posttraumatic Stress Disorder: An Immunological Disorder?2021The Relationship Between Inflammation and Post-traumatic Stress Disorder 2017Immune signaling mechanisms of PTSD risk and symptom development: insights from animal models 2019Association of Prospective Risk for Chronic PTSD Symptoms With Low TNFα and IFNγ Concentrations in the Immediate Aftermath of Trauma Exposure 2016PTSD, a Disorder with an Immunological Component 2017Serum levels of interleukins IL-6 and IL-10 in individuals with posttraumatic stress disorder in a population-based sample

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