Current viral risks of blood and blood products

Roger Y. Dodd

64 citations0/0 files storedAnnals of Medicine

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Blood donation and transfusion practices Hepatitis C virus research Blood transfusion and management

Abstract

A number of viruses may be transmitted by blood transfusion, the most important of these are HIV, human T-cell lymphotrophic retrovirus (HTLV), hepatitis B virus (HBV), and hepatitis C virus (HCV). A series of overlapping safety measures are in place and are being improved and supplemented continuously. As a result, the risk of transmission of these viruses in the USA has been reduced to between one and four per million blood components transfused.

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References

1996The Risk of Transfusion-Transmitted Viral Infections 1988Transmission of Human Immunodeficiency Virus (HIV) by Blood Transfusions Screened as Negative for HIV Antibody 1995Estimated Risk of Transmission of the Human Immunodeficiency Virus by Screened Blood in the United States 1989Exposure of Patients to Human Immunodeficiency Virus through the Transfusion of Blood Components That Test Antibody-Negative 1981Donor transaminase and recipient hepatitis. Impact on blood transfusion services 1981Donor Transaminase and Recipient Hepatitis 1991Risk of human immunodeficiency virus (HIV) transmission by blood transfusions before the implementation of HIV‐1 antibody screening 1991Evaluation of Screened Blood Donations for Human Immunodeficiency Virus Type 1 Infection by Culture and DNA Amplification of Pooled Cells

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2003Impact of changes in viral marker screening assays 2010Can the nucleic acid amplification test (NAT) be an alternative to the serologic tests? A prospective study, the results of 18,200 blood donors from the Turkish Red Crescent 2002Reduced frequency of blood donors with false‐positive HIV‐1 and ‐2 antibody EIA reactivity after elution of low‐affinity nonspecific natural antibodies

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