Olanzapine in the Treatment of Aggression and Tics in Children with Tourette's Syndrome—A Pilot Study

Robyn J. Stephens · Chris Bassel · Paul Sandor

102 citations0/0 files storedJournal of Child and Adolescent Psychopharmacology

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Obsessive-Compulsive Spectrum Disorders Schizophrenia research and treatment Attention Deficit Hyperactivity Disorder

Abstract

OBJECTIVE: The aim of this study was to examine the effects of olanzapine on aggressive behaviour and tic severity in children with Tourette's Syndrome (TS). METHOD: Ten (10) subjects (aged 7-13 years) with a primary diagnosis of TS and a history of aggressive behaviour were treated in a single-blind, 2-week placebo run-in, 8-week treatment phase trial. The starting dose of olanzapine was 1.25-2.5 mg/day and was titrated at biweekly intervals, as tolerated. The mean dosage at the end of the trial was 14.5 mg/day. RESULTS: All 10 subjects completed the study. Olanzapine produced clinically and statistically significant reductions of aggression and tic severity from baseline to trial completion, as measured by the Achenbach Child Behavior Checklist (CBCL) and Yale Global Tic Severity Scale (YGTSS). Weight gain during the treatment period was the most common adverse effect (range 2-20 lbs: group mean 12.0 lbs +/- 5.71). No other significant adverse effects were observed during the 10-week trial. CONCLUSION: The results of this trial confirm clinical observations that olanzapine may be an effective treatment for aggression and tics in children with Tourette's syndrome. Olanzapine was generally well tolerated, although significant weight gain was observed throughout the trial.

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References

1989The Yale-Brown Obsessive Compulsive Scale 1989The Yale Global Tic Severity Scale: Initial Testing of a Clinician-Rated Scale of Tic Severity 2000An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries 2001Basal ganglia dysfunction in Tourette’s syndrome: a new hypothesis 1989Controlled Study of Haloperidol, Pimozide, and Placebo for the Treatment of Gilles de la Tourette's Syndrome 2000Ziprasidone Treatment of Children and Adolescents With Tourette's Syndrome: A Pilot Study 2000Tourette's Disorder: Epidemiology and Comorbidity in Primary School Children 1997Relative efficacy of haloperidol and pimozide in children and adolescents with Tourette's disorder

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2006Randomized Trial of Parent Management Training in Children With Tic Disorders and Disruptive Behavior 2008Effectiveness and Tolerability of Open Label Olanzapine in Children and Adolescents with Tourette Syndrome 2011Tourette syndrome and other tic disorders 2008Aripiprazole Treatment of Children and Adolescents with Tourette Disorder or Chronic Tic Disorder

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