Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome

Michael H. Bloch · James Frederick Leckman · Hongtu Zhu B · Bradley S. Peterson

326 citations0/0 files storedNeurology

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Obsessive-Compulsive Spectrum Disorders Neurological disorders and treatments Stuttering Research and Treatment

Abstract

BACKGROUND: Most children with Tourette syndrome (TS) experience a marked decline in the severity of tic symptoms during adolescence. Currently no clinical measures can predict whose tic symptoms will persist into adulthood. Previous cross-sectional imaging studies have identified reduced caudate nucleus volumes in subjects with TS. OBJECTIVE: To evaluate whether caudate nucleus volumes in childhood can predict the severity of tic or obsessive-compulsive symptoms at follow-up in early adulthood. METHODS: In a prospective longitudinal study, clinical status and basal ganglia volumes of 43 children with TS were measured on high-resolution magnetic resonance images before age 14 years. Follow-up clinical assessments were conducted after age 16 years, an average of 7.5 years later. Linear regression and Tobit regression analyses were used to assess the association of basal ganglia volumes measured in childhood with the severity of tic and obsessive-compulsive disorder (OCD) symptoms at the time of childhood MRI and at follow-up in early adulthood. RESULTS: Volumes of the caudate nucleus correlated significantly and inversely with the severity of tic and OCD symptoms in early adulthood. Caudate volumes did not correlate with the severity of symptoms at the time of the MRI scan. CONCLUSIONS: Caudate volumes in children with Tourette syndrome predict the severity of tic and obsessive-compulsive symptoms in early adulthood. This study provides compelling evidence that morphologic disturbances of the caudate nucleus within cortico-striatal-thalamo-cortical circuits are central to the persistence of both tics and obsessive-compulsive symptoms into adulthood.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 326 citations exist upstream.

References

1997Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data 1976The Global Assessment Scale 1989The Yale Global Tic Severity Scale: Initial Testing of a Clinician-Rated Scale of Tic Severity 1997Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity 2000Tourette syndrome, associated conditions and the complexities of treatment 1998Course of Tic Severity in Tourette Syndrome: The First Two Decades 2003Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome 1998A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome

Cited by

2010The neurobiology of repetitive behavior: …and men 2006Tourette Syndrome: The Self Under Siege 2012The functional anatomy of Gilles de la Tourette syndrome 2007Tourette Syndrome and Tic Disorders: A Decade of Progress 2011European clinical guidelines for Tourette Syndrome and other tic disorders. Part I: assessment

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.