Brain serotonin determines maternal behavior and offspring survival

Mariana Angoa‐Pérez · Catherine E. Sykes · Shane Alan Perrine · Michael W. Church · Donald M. Kuhn

65 citations0/0 files storedGenes Brain & Behavior

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Neuroendocrine regulation and behavior Neurotransmitter Receptor Influence on Behavior Stress Responses and Cortisol

Abstract

Maternal care is an indispensable component of offspring survival and development in all mammals and necessary for reproductive success. Although brain areas regulating maternal behaviors are innervated by serotonergic afferents, very little is known about the role of this neurotransmitter in these behaviors. To evaluate the contribution of serotonin to maternal care, we used mice with a null mutation in the gene for tryptophan hydroxylase-2 (TPH2), which results in a genetic depletion of brain serotonin, and tested them in a wide range of maternal behavior paradigms. We found that litters born to and reared by TPH2(-/-) mothers showed decreased survival, lower weaning weights and increased cannibalization. In addition, TPH2(-/-) mothers performed poorly in pup retrieval, huddling, nest construction and high-arched back nursing. Aggression in TPH2(-/-) dams was not triggered by lactation and was steadily high. Survival and weaning weight deficits of TPH2(-/-) pups were rescued by cross-fostering and in litters of mixed genotype (TPH2(-/-) and TPH2(-/+) ). However, the maternal behaviors of TPH2(-/-) dams did not improve when rearing either TPH2(+/+) pups or mixed-genotype litters. In addition, TPH2(-/-) pups significantly worsened the behavior of TPH2(+/+) dams with respect to cannibalism, weaning weight and latency to attack. Olfactory and auditory functions of TPH2(-/-) females or anxiety-like behaviors did not account for these maternal alterations as they were equal to their TPH2(+/+) counterparts. These findings illustrate a profound influence of brain serotonin on virtually all elements of maternal behavior and establish that TPH2(-/-) pups can engender maladaptive mothering in dams of both genotypes.

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1963Maternal behavior in mammals.2011Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action 2008Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats 2002Sensory, hormonal, and neural control of maternal aggression in laboratory rodents 2007Natural variations in postpartum maternal care in inbred and outbred mice 2001Maternal defence as an emotional stressor in female rats: correlation of neuroendocrine and behavioural parameters and involvement of brain oxytocin 2010Maternal nurturing is dependent on her innate anxiety: The behavioral roles of brain oxytocin and vasopressin 2002Maternal behavior and developmental psychopathology

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