Ghrelin and Obestatin Circadian Levels Differentiate Bingeing-Purging from Restrictive Anorexia Nervosa

Natacha Germain · Bogdan Galusca · Dominique Grouselle · Delphine Frère · Stéphane Billard · Jacques Epelbaum +1 more

105 citations0/0 files storedThe Journal of Clinical Endocrinology & Metabolism

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Eating Disorders and Behaviors Hypothalamic control of reproductive hormones Regulation of Appetite and Obesity

Abstract

CONTEXT: Anorexia nervosa (AN) patients present with restrictive food behavior (AN-R). Some of them develop episodes of bulimia (AN-BP) without any clear pathophysiological explanation to date. Their clinical differentiation is important but not easily performed. Orexigenic/anorexigenic peptides measurements could provide some clues for that matter. OBJECTIVE: The objective of the study was to determine whether the circadian profile of total and acylated ghrelin, obestatin, and peptide YY (PYY) levels is different in AN-R subjects when compared with AN-BP patients. DESIGN AND SETTINGS: This was a cross-sectional study in an endocrinological unit. PATIENTS AND CONTROL SUBJECTS: Four groups of age-matched young women: 22 AN-R, 10 AN-BP, 16 normal-weight bulimia nervosa (BN), and nine controls. MAIN OUTCOME MEASURES: Twelve-point circadian profiles of plasma total and acylated ghrelin, obestatin, and PYY were measured. RESULTS: Total and acylated ghrelin and obestatin circadian levels were increased in AN-R when compared with controls but decreased in both AN-BP and BN groups (P < 0.001). PYY was decreased in all groups with eating disorders. Acylated to total ghrelin ratio was decreased in AN-BP and BN (P < 0.001), whereas obestatin to acylated ghrelin and PYY to acylated ghrelin ratios were increased in both groups with bingeing-purging behavior (P < 0.0001). CONCLUSIONS: Patients with AN-associated bingeing-purging behavior present a very different profile of appetite regulatory peptides when compared with the pure restrictive type. The assessment of ghrelin (and eventually obestatin) could be of particular interest for differential diagnosis. Very low ghrelin levels and increased anorexigenic to orexigenic peptide ratios suggest either a lack of adaptation to a starvation state or a higher facility to cope with undernutrition.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 105 citations exist upstream.

References

2013Diagnostic and Statistical Manual of Mental Disorders 2008Diagnostic Crossover in Anorexia Nervosa and Bulimia Nervosa: Implications for DSM-V 2000Perfectionism in Anorexia Nervosa: Variation by Clinical Subtype, Obsessionality, and Pathological Eating Behavior 2002Longitudinal comparison of anorexia nervosa subtypes 2003Fasting plasma ghrelin levels in subtypes of anorexia nervosa 2005Plasma Ghrelin Concentrations Are Lower in Binge-Eating Disorder1–3

Cited by

2011Endocrine Dysregulation in Anorexia Nervosa Update 2018MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update 2016Faim et satiété, contrôle comportemental de la prise alimentaire

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.