Clinical features and associated psychopathology in a Tourette syndrome cohort

Valsamma Eapen · Paul J. Fox-Hiley · Sube Banerjee · Mary May Robertson

150 citations0/0 files storedActa Neurologica Scandinavica

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Obsessive-Compulsive Spectrum Disorders Psychoanalysis and Psychopathology Research Stuttering Research and Treatment

Abstract

OBJECTIVE: This study explored in detail the association between tic symptomatology, related clinical variables, and psychopathology in 91 consecutive adult TS subjects from a UK clinic. METHODS: Consecutive patients from a specialized Tourette clinic who met the DSM-III criteria for TS were evaluated using standardized rating scales for Tourette syndrome and other psychopathology. RESULTS: The male female ratio in our cohort was 1.8:1. Significantly more males had an earlier age at onset of TS and history of birth complications. Obsessive compulsive behaviors in the patient was positively correlated with presence of attention deficit hyperactivity disorder and self-injurious behaviors. With regard to adult psychopathology, principal components factor analysis yielded two factors, 'obsessionality' and 'anxiety/depression', which accounted for 72% of the variance. CONCLUSION: Our results support the high occurrence of anxiety, depression and obsessionality in adult TS subjects.

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References

1961An Inventory for Measuring Depression 2012Diagnostic and Statistical Manual of Mental Disorders 1995A family study of obsessive-compulsive disorder 2000An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries 1997Symptoms of obsessive-compulsive disorder 1999Use of Factor-Analyzed Symptom Dimensions to Predict Outcome With Serotonin Reuptake Inhibitors and Placebo in the Treatment of Obsessive-Compulsive Disorder 2000Tourette syndrome, associated conditions and the complexities of treatment 1966A Short Clinical Diagnostic Self-rating Scale for Psychoneurotic Patients

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