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For the case of one variable Berkson has shown that a standard statistical analysis can be justified even when the levels of the independent variable x are subject to error provided that the response relationship is linear in x. parallel result is true for any number of independent variables. For a non-linear relationship the effect depends on the design chosen. The two-level factorials and fractionals and also particular partially duplicated fractionals are remarkably robust with respect to errors in the x's. This paper, which appeared originally in the Bulletin of the International Statistical Institute, Vol. XXXVIII: Part III, Tokyo, 1961, pp. 339–355, is reprinted in Technometrics with the kind permission of the author and the editors of the Bulletin of the International Statistics Institute.
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