Brain Perfusion Abnormalities in Gilles de la Tourette's Syndrome

Durval C. Costa · Bettina Schmitz · Michael Trimble · Peter Josef Ell · Mary May Robertson

99 citations0/0 files storedThe British Journal of Psychiatry

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Obsessive-Compulsive Spectrum Disorders Neural and Behavioral Psychology Studies Neurological disorders and treatments

Abstract

BACKGROUND: Functional brain imaging with technetium-99m d,l-hexamethyl propyleneamine oxime (HMPAO) Single Photon Emission Tomography (SPET) allows us to explore the cerebral pathophysiology of Gilles de la Tourette's Syndrome (GTS). METHOD: Fifty patients and 20 controls were examined. Patients were rated for tic severity and mood. Scans were analysed quantitatively using internal ratios to the occipital cortex. RESULTS: Patients different from controls on measures of relative blood flow to the left caudate, anterior cingulate cortex and the left dorsolateral prefrontal cortex. Severity of tics was related to hypoperfusion of the left caudate and cingulate and a left medial temporal region. Hypoperfusion in the left dorsolateral prefrontal region was related to mood. CONCLUSIONS: The areas found to be hypoperfused in this study are consistent with known functions of fronto-striatal circuits. A wide range of perfusion patterns is seen, however, and no characteristic patterns for behavioural subgroups has been documented with this technique.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 99 citations exist upstream.

References

1961An Inventory for Measuring Depression 1993Reduced basal ganglia volumes in Tourette's syndrome using three‐dimensional reconstruction techniques from magnetic resonance images 1993Volumetric MRI changes in basal ganglia of children with Tourette's syndrome 1989The Gilles de la Tourette Syndrome: the Current Status 1993Obsessions in obsessive-compulsive disorder with and without Gilles de la Tourette's syndrome

Cited by

2004Dopamine transporter density of the basal ganglia assessed with [123I]IPT SPECT in drug-naive children with Tourette's disorder 2004Neurobiology and neuroimmunology of Tourette?s syndrome: an update 2004A Pilot Safety Study of Repetitive Transcranial Magnetic Stimulation (rTMS) in Tourette’s Syndrome 2004Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP‐CIT/SPECT study

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.