Pre- and post- donation haematological values in healthy donors undergoing plateletpheresis with five different systems.

Sudipta Sekhar Das · Rajendra Chaudhary · Shashank Kumar Ojha · Dheeraj Khetan

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Blood donation and transfusion practices Platelet Disorders and Treatments Blood transfusion and management

Abstract

BACKGROUND: Although automated cell separators have undergone a lot of technical refinements, attention has been focused more on the quality of platelet concentrates than on donor safety. We planned this prospective study to observe the effects of automated plateletpheresis on normal haematological values of healthy donors and to determine whether the haematological alterations had any clinical consequences. STUDY DESIGN AND METHODS: The study was conducted on 457 healthy, first-time plateletpheresis donors over a period of 26 months. The plateletpheresis procedures were performed using five different cell separators and various pre- and post-donation haematological values such as haemoglobin concentration (Hb), haematocrit (Hct), platelet and white blood cell (WBC) counts, mean platelet volume and platelet distribution width were measured in all donors. RESULTS: We observed that the Hb, Hct, platelet and WBC counts decreased significantly in the donors (p<0.01) after each procedure, without there being significant changes in mean platelet volume or platelet distribution width. The decreases in Hb and Hct were significantly greater with the CS 3000 and Amicus machines, while the decreases in platelet and WBC counts were significantly greater with the CS 3000 and Fresenius separators. CONCLUSION: Although a significant drop in complete blood count was observed in all donors, none manifested features of thrombocytopenia or anaemia. Nevertheless, more prospective studies on this aspect are required in order to establish guidelines for donor safety in apheresis and also to help in assessing donor suitability, especially given the present trend of double product apheresis collections.

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2001Sustained decreases in platelet count associated with multiple, regular plateletpheresis donations

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2014Changes in pre- and post-donation haematological parameters in plateletpheresis donors 2016Recovery of Platelet Count among Apheresis Platelet Donors 2019Effect of plateletpheresis on hematocrit, hemoglobin and erythrocyte count: Meta-analysis 1980–2018 2020Analysis of Donor Safety in High Yield Plateletpheresis Procedures: An Experience from Tertiary Care Hospital in South India 2018Double Dose Plateletpheresis: A Savior to Shrinking Donor Pool and Platelet Inventory Management 2021The impact of blood donation on blood counts and ferritin levels: A multi-center study from the Eastern Mediterranean region 2020The Play of Citrate Infusion with Calcium in Plateletpheresis Donors 2021Effect of double dose plateletpheresis on target yield and donor platelet recovery

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