Articlebronze2007

Genetic risk of depression and stress-induced negative affect in daily life

Marieke Wichers · Inez Myin‐Germeys · Nele Jacobs · Frenk P. M. L. Peeters · Günter Kenis · Catherine A Derom +3 more

178 citations0/0 files storedThe British Journal of Psychiatry

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Mental Health Research Topics Genetic Associations and Epidemiology Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Abstract

BACKGROUND: A bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess. AIMS: To assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life. METHOD: The experience sampling method was used to collect multiple appraisals of daily life event-related stress and negative affect in 279 female twin pairs. Cross-twin, cross-trait associations between dailylife mood bias and DSM-IV depression were conducted. RESULTS: Probands whose co-twins were diagnosed with lifetime depression showed a stronger mood bias to stress than those with co-twins without such a diagnosis, independent of probands' current depressive symptoms and to a greater extent in monozygotic twins than in dizygotic twins. CONCLUSIONS: Genetic liability to depression is in part expressed as the tendency to display negative affect in response to minor stressors in daily life. This trait may represent a true depression endophenotype.

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References

1987Validity and Reliability of the Experience-Sampling Method 1991Personality and the Problems of Everyday Life: The Role of Neuroticism In Exposure and Reactivity to Daily Stressors 2004The Interrelationship of Neuroticism, Sex, and Stressful Life Events in the Prediction of Episodes of Major Depression 1999The role of neuroticism in daily stress and coping.2006A Population-Based Twin Study of the Relationship Between Neuroticism and Internalizing Disorders 2001Gender Differences in the Rates of Exposure to Stressful Life Events and Sensitivity to Their Depressogenic Effects 2004Environmentally Mediated Risks for Psychopathology: Research Strategies and Findings 2006The Experience of Psychopathology: Investigating Mental Disorders in their Natural Settings

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